Addiction & Alcoholism

CBD & Opiate Addiction

Much research demonstrates that cannabis promotes the safety and efficacy of opioids.

Cannabis Legalization & Opioid Overdose

Orange pill bottles and spilled white pills

Opioids leave much to be desired in medical treatment. They are highly addictive, very lethal, and not all that effective for treating chronic pain. Cannabis, particularly THC, is promising for its opiate-sparing properties: preclinical work indicates that cannabis synergizes with the painkilling effects of opioids and reduces the development of tolerance (perhaps because of this synergy) but does not increase opioid-induced respiratory depression which leads to death. Moreover, states that legalize cannabis see a decrease in opioid prescriptions.

THC Makes Oxycodone Safer

Many prohibitionist arguments are being flipped on their heads. CBD’s anti-anxiety effects have replaced much of the reefer madness mentality. Rather than causing lung cancer, marijuana appears to have anti-cancer activity, if anything. And in spite of the gateway theory, whereby casual cannabis use supposedly escalates to heroin, we find that cannabis helps to treat pain and reduce opiate use. An animal study out of the Scripps Research Institute reaffirms that THC generally reduces the addictiveness of opioids.

Placebo Genetics

sugar cubes on wooden table

Throughout history, cannabis has been described as a treatment for hundreds of different conditions. If scientists find it hard to believe cannabis can do so much, they may chalk up the results as just a placebo. But the placebo effect is powerful. It accounts for roughly half of the efficacy of opioids and antidepressants. And, ironically, the placebo effect actually functions in part through the endocannabinoid system.

Cannabis Mitigates Alcohol Toxicity

bud on top of beer can

Heavy or even moderate drinking causes maladaptions in humans, ranging from cardiovascular disease to cirrhosis. Underlying many of these ill effects is alcohol’s ability to amplify inflammation. But the immune system is immensely complex, and “inflammation” is a catch-all term that accounts for most degenerative and age-related disease, so it is important to distinguish the specific molecules promoting inflammation. Interleukins are a class of proteins that orchestrate the movement of immune cells – most, but not all, increase inflammation.

The Gateway to Opiates

barbed wire fence against blue sky

The gateway theory of addiction is a slippery slope fallacy. It argues that when people are introduced to mild drugs like cannabis, they later escalate to dangerous drugs like amphetamines and opioids. In the era of reefer madness, this was an excuse to demonize cannabis by associating it with lethal drugs. Although the theory is wrong, there are a few real aspects of addiction it captures. Opioids are devastating in part because of tolerance and sensitization. When the body is exposed to opioids, it tones down endogenous opiate activity however it can.

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